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Background: Psychological stress is often experienced without realized. One of the causes is the inverted sleep-guard pattern. Psychological stress causes oxidative stress resulting in increased reactive oxygen species (ROS). ROS as a trigger of high free radicals exceeds the amount of antioxidants in the body causing accumulation of oxidative damage and increase level of MDA (Malondialdehide) as one of psychological stress markers. High MDA may be prevented by high antioxidant food that found in plants. One of plants that use to prevent this, called Jujube leaves. Jujube leaves contain flavonoid can lower MDA. The aim of this study is to analize the influence of Jujube Leaves brewed to MDA levels in white rat strains wistar exposed to psychological stress by compared the difference of MDA levels in each group. Materials and Methods: The type of research that used in this study is true experimental, by post-test control group design. Psychological stress condition of wistar rats was made by changing the sleep-patterns reverse. The doses of jujube leaves are given for 3,9 gr, 7,9 gr, and 15,8 gr. Statistical analysis that used is ANOVA. Result: Based on statistical analysis, showed that there are differences of MDA levels in stress control group, first treatment, second treatment, and third treatment, significant (p. < 0.05). Levels of MDA in the normal group compared with the high MDA group (stress control group). The third treatment showed a significant difference (p. < 0.05). Conclusion: Jujube leaves brewed can decreased MDA levels after treatment, those can be due to the flavonoid and polyphenol of Jujube leaves brewed.

EFFECT OF JUJUBE LEAVES BREWED TO MALONDIALDEHIDE (MDA) LEVEL OF WISTAR RATS EXPOSED PSYCHOLOGICAL STRESS