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Fungal infections; in general; have long been a major therapeutic challenge.The therapeutic arsenal has been limited, and the use of drugs has been restricted due to toxicity or unfavorable pharmacokinetic profiles. Furthermore resistance to antifungal drugs has been observed.Otomycosis is an acute, subacute or chronic fungal infection of the pinna, the external auditory meatus and the ear canal. However the disease may occur in the Investigation of the antifungal activity of some non-antifungal drugs in clinical isolates of otomycosis: In vitro study