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Objective: To determine the sensitivity and specificity of mesothelin&#x0D;compared with Ca-125 as a tumor marker in predicting ovarian malignancy.&#x0D;Method: The cross sectional study design with diagnostic tests was&#x0D;conducted in 30 samples of patients undergoing elective laparotomy&#x0D;due to ovarian tumor. We compared the sensitivity and specificity&#x0D;between mesothelin and Ca-125, then the data were analyzed using&#x0D;SPSS software version 22.0.&#x0D;Result: According to the ROC curve analysis, optimal sensitivity and&#x0D;specificity value of mesothelin was 63.2% and 54.5% at a cut-off&#x0D;point of 0.45 pg/ml; or 42.1% and 72.7% at a cut-off point of 0.55&#x0D;pg/ml. While the value of both optimal sensitivity and specificity of&#x0D;Ca-125 was 73.7% and 63.6% at a cut-off point of 46.63 U/ml.&#x0D;Conclusion: Mesothelin and Ca-125 are not different significantly&#x0D;for the AUC value of 50%. Due to higher sensitivity and specificity of&#x0D;Ca-125 than mesothelin, Ca-125 is still used as tumor marker for&#x0D;screening the ovarian malignancy.&#x0D;[Indones J Obstet Gynecol 2016; 4-2: 107-110]&#x0D;Keywords: Ca-125, mesothelin, ovarian malignancy

Mesothelin versus Ca125 in Screening the Ovarian Malignancy