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Objective: To identify relationship between progesterone receptor&#x0D;gene polymorphism promoter region +331G/A with the risk of&#x0D;endometriosis.&#x0D;Method: An observational case-control study. Population are women&#x0D;with endometriosis and/or adenomyosis who have been performed&#x0D;laparotomy/laparoscopy at Obstetrics and Gynecology&#x0D;Department Dr. Mohammad Hoesin General Hospital Palembang,&#x0D;January-November 2013. Subjects fulfilled inclusion criteria, given&#x0D;informed consent and performed blood sampling continued by PCRRFLP.&#x0D;Results were divided into A/A genotype (homozygote mutant),&#x0D;G/A (heterozygote mutant), and G/G (homozygote wild type).&#x0D;Data were analyzed by SPSS 21.0 version.&#x0D;Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in&#x0D;case group and 14 (26.4%) in control. +331A/A genotype was not&#x0D;found in both groups. There was significant increase risk of endometriosis&#x0D;in women carrying genotype +331G/A to those with genotype&#x0D;+331G/G with OR 3.29 (p

Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis