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Objective: To evaluate the theurapeutic response and acute toxicity&#x0D;of neoadjuvant chemotherapy between the combination of Platinum&#x0D;and Ifosfamide, and the combination of Platinum, Vincristine and&#x0D;Bleomycin in Cervical Carcinoma Stage IB2 and then continued with&#x0D;radical hysterectomy and pelvic lymphadenectomy.&#x0D;Method: Thirteen samples received neoadjuvant chemotherapy of&#x0D;Platinum and Ifosfamide and 17 samples received neoadjuvant chemotherapy&#x0D;of Platinum, Vincristine and Bleomycin, after receiving&#x0D;the neoadjuvant chemotherapy, clinically complete response samples&#x0D;underwent radical hysterectomy and pelvic lymphadenectomy&#x0D;(PI VS PVB = 3 VS 1). Histopathology examination was performed to&#x0D;evaluate the presence of malignant viable cells at the cervix, pelvic&#x0D;lymph node metastasis and parametrium metastasis. Acute toxicity&#x0D;evaluation was performed based on gastrointestinal, genitourinarius&#x0D;and hematology sign and symptom.&#x0D;Result: Theurapeutic response of PI is 1.12 higher than PVB&#x0D;(p&gt;0.05). Subanalysis of group response of PI is 1.962 higher than&#x0D;PVB. PI and PVB have the same risk to have pelvic lymph node metastasis,&#x0D;but not parametrial metastasis. There were no differences&#x0D;in terms of the risk of gastrointestinal, genitourinarius and hematologic&#x0D;toxicity between PI and PVB.&#x0D;Conclusion: There was no statistical difference in clinical and&#x0D;pathological response, and also in acute toxicity between the two&#x0D;combination (p&gt;0.05).&#x0D;[Indones J Obstet Gynecol 2016; 1: 47-51]&#x0D;Keywords: acute toxicity, cervical carcinoma stage IB2, neoadjuvant&#x0D;chemotherapy, response

indonesian journal of obstetrics and gynecology

Theurapeutic Response of Neoadjuvant Chemotherapy between Platinum and Ifosfamide Combination and Platinum, Vincristine and Bleomycin Combination in Cervical Carcinoma Stage IB2