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Globally, cervical cancer is the third most common female cancer, with over 500,000 new cases diagnosed every year according to the WHO.1 More than 85% of these cases and deaths occur in economically developing and medically underserved countries, largely in sub-Saharan Africa, South America, and South-Central Asia, where it is often the second most common female cancer. There are still almost 300,000 deaths from this disease recorded annually.2 According to the staging of cervical cancer by the International Federation of Gynecology and Obstetrics (FIGO) in 2009, stage IIB is a locally advanced stage of disease, characterized by tumor larger than 4 cm, with involvement of the upper b of the vaAbstract Objective: To evaluate the clinical efficacy, operability, radicality, toxicity, and incidence of recurrences of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy (RH) among patients with stage IIB cervical cancer. Method: This is an observational clinical study at Dr. Moh. Hoesin Hospital, Palembang. Data were analyzed from 27 patients who matched the inclusion criteria and underwent 3 cycles of neoadjuvant chemotherapy (NAC) with Paclitaxel (75 mg/m2) in combination with Cisplatin (50 mg/m2) and Docetaxel (75 mg/m2) combined with Carboplatin (300 mg/m2) according to AUC 6, followed by radical hysterectomy from January 2012 until December 2013. Result: The operability rate after NAC was 96.4%. Lymph node metastases were negative in 75% of patients, and we found bilateral lymph node metastases in 14.3% of patients. Parametric infiltrations were negative in 85.7% of the patients, and positive in 14.3% of patients. No vaginal infiltrations were found. As much as 89.3% of the patients did not experience any side effect, while anemia and thrombocytopenia were found in 10.8% of the patients. We found that 7.1% of patients had recurrences within 6 months interval. Conclusion: NAC followed by radical hysterectomy showed significant advantages for patients with stage IIB cervical cancer, with fewer side effects. However, long-term evaluation and a larger number of patients are required to confirm this result. [Indones J Obstet Gynecol 2015; 2: 106-109]

Clinical Evaluation of Neoadjuvant Chemotherapy Followed by Radical Hysterectomy in the Management of Cervical Cancer Stage IIB