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579 THYROID NODULES AND PREGNANCY Adaptation of the thyroid gland during pregnancy Many physiologic changes involving the thyroid gland occur during pregnancy. Iodine requirements increase due to the elevated renal iodine clearance, iodine transfer to the fetal compartment, augmented levels of serum T4-binding globulin, and inner-ring deiodination of T4 and T3 exerted by placenta (1). These changes are associated with an increase of thyroid hormones production by about 1.5-fold and an increase in iodine requirements by about 50% with a consequent augmented thyroid activity (1).

journal of endocrinological investigation

Thyroid nodule and differentiated thyroid cancer management in pregnancy. An Italian Association of Clinical Endocrinologists (AME) and Italian Thyroid Association (AIT) Joint Statement for Clinical Practice.