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The reproductive function of cows is ensured by a homeostasis system. The aim of this study to investigate scientific data and analyze modern practical approaches related to metabolic disorders. Also investigating immune response. The object of the research was the cows (Bos taurus taurus) of Ukrainian Black-and-White dairy breed.  Using the method in groups and periods. The control group of animals The control group of animals (C1, n=137) – cows with a physiological of pregnancy (248-255 days). Re-examination of control animals (C2, n=137) was carried out during the postpartum period. The first experimental group (E1, n = 32) consisted of animals diagnosed with preeclampsia. Cows with a subclinical course of ketosis constituted the second group (E2, n = 52).   The development of preeclampsia of cows was accompanied by an increase in the content of medium-sized peptides from 0.2 ± 0.01 to 0.3 ± 0.03 Mol.Wt. (P < 0.01), and an increase in the level of average molecular circulating immune complexes. It is proved that an imbalance in the diet and a deficiency of metabolic energy during the dry period and for 6-8 weeks after birth negatively affects the health of animals, is the cause of metabolic disorders and the manifestation of reproductive pathologies.

The importance of metabolic processes and immune responses in the development of pathology of cows during pregnancy and postpartum periods