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Controlled illumination at targetted locations (targeted illumination) and imaging at high switching speed have found significant applications in different frontiers of science and technology such as optogenetics, photodynamic therapy (PDT), neurophotonics, and medical imaging. Although there are numerous optical systems reported with targeted illumination ability, most of these are modified standard (bench top) microscopes, hence not suitable for in vivo applications. Therefore, there is a critical need to develop optical imaging systems with targeted illumination suitable for in vivo studies. The small diameter, user-defined length and high mechanical flexibility of fiber optic imaging bundle (FOIB) facilitates its positioning at remote and difficult-toaccess in vivo sites. Recently, few FOIB based studies are reported, which have shown adaptation of targeted illumination. However, image resolution and switching speed achieved with these methods are found to be limited to 10 11m and 20 Hz, respectively. In order to investigate biological or chemical processes, the methodology adopted or equipment used should be able to provide higher resolution, faster-switching speed and an option for targeted illumination and imaging. Moreover, images obtained with FOIB probes are always affected by pixelation noise which deteriorates the image resolution and contrast. Though there are many algorithms to remove pixelation noise, objective comparison of these algorithms are not possible due to the non-availability of a common test image database. Also, I ATTENTION: The Singapore Copyright Act applies to the use of this document. Nanyang Technological University Library

Investigations into high resolution optical fiber probe for targeted illumination and imaging around opaque obstacles