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iv Chapter I: Introduction  1 1.1 Afflictions related to the abnormal cell surface protein, Integrin  1 1.2 Diversity of the integrin super family  3 1.3 Receptors and ligands of integrins  5 1.4 Studies on the function of integrins  5 1.5 General structure of integrins  6 1.6 The domain organization of the α-subunit  6 1.7 The domain organization of the β-subunit  7 1.8 Structural transitions of integrins  8 1.9 Factors affecting integrin structural transitions  9 1.10 Structural studies of the open, closed and intermediate conformations of integrin  12 1.11 Detailed structural insights into the extracellular domains of integrin  13 1.12 Recent crystal structures of the extracellular domains of the integrin molecule  15 1.13 Observation of global structural transitions in integrin molecules using Electron Microscopy (EM)  19 1.14 Detailed structural insights into the individual domains of integrins  23 1.15 Structural insights into the integrin β-subunit domains  23 ATTENTION: The Singapore Copyright Act applies to the use of this document. Nanyang Technological University Library

Structures and interactions of the leukocyte-specific integrins cytoplasmic tails