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X THESIS SUMMARY XI CHAPTER 1: INTRODUCTION1 1.1 Apoptosis 2 1.2 Survivin3 1.2.1 Survivin as cell death regulator 6 1.2.2 Survivin as mitotic facilitator 7 1.3 Survivin and cancer 11 1.4 Ubiquitin-proteasome proteolysis 12 1.5 Regulation of apoptosis by ubiquitination14 1.6 Nucleocytoplasmic transport 15 1.6.1 Nuclear pore complex (NPC) 16 1.6.2 The roles of nuclear transport receptors (NTRs)17 1.6.3 RanGTP gradient 18 1.7 Nucleocytoplasmic transport and apoptosis22 1.8 Aim of present study25 CHAPTER 2: MATERIALS AND METHODS 27 2.1 Cell culture, transfections and drug treatments 28 2.2 Immunofluorescence microscopy 28 2.3 Fluorescense Resonance Energy Transfer (FRET) 29 2.4 Preparation of cell extracts, immunoblotting and immunoprecipitation29 2.5 Antibodies 30 2.6 RNAi mediated silencing of Mst1 and Survivin30 2.7 Molecular cloning 33 2.8 Time-lapse imaging33

The role of bidirectional nucleocytoplasmic transport in apoptosis