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The last decade has seen an abundance of research in the area of protein conjugation. Labeling of proteins at a specific site with small molecules can advance our understanding of biochemical events. With this novel technology, investigation of protein expression, localization, protein-protein interaction and their conformational changes during the cell cycle can be studied. Herein, we will report the methodology developed for the site specific functionalization of peptides and protein through the formation of carbon-carbon bond.

Part I Chemical functionalization of peptides and proteins Part II Synthetic studies towards the total synthesis of Platensimycin