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G-quadruplex is a secondary non-canonical structure of nucleic acid which gained popularity due to increasing evidence of its biological function, potential therapeutic prospect and nanotechnology application. This research addresses multiple angles of G-quadruplex properties including its dynamics, ligand binding kinetics, several novel topologies and potential role in biofilm networking through combination of biophysical techniques. NMR spectroscopy as a biophysical technique has been constantly developed towards simpler and more effective methods in resolving growing biological problems. The methodologies presented in this thesis – lineshape analysis and NOESY exchange analysis, contribute as effective options in measuring G-quadruplex dynamics. Furthermore, the applications of NMR spectroscopy explored here add insights on: (1) Vacancy-bearing G-quadruplex as metabolite binder; (2) fundamentals of G-quadruplex fold-back diagonal loop scaffold and drug design; (3) expansion of G-quadruplex diversity based on the existence of left-handed right-handed junction; and (4) potential biological importance of Gquadruplex in biofilm network. FERNALDO RICHTIA WINNERDY

Development and application of NMR spectroscopy in G-quadruplexes : structure, dynamics and formation in biofilm