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Background: The incidence of acoustic trauma after gunshot exposure in students of the Sekolah Polisi Negara (SPN) is quite high. Malondialdehyde (MDA) is a compound that can portray oxidative stress due to free radicals. The correlation between the levels of MDA and the hearing threshold frequency post gunshot exposure could be used as the base for administering antioxidants to prevent acoustic trauma. Objective: To find out the correlation between the levels of MDA and the hearing threshold frequency post gunshot exposure, in East Java SPN students. Method: An observational analytic study with a retrospective cross sectional approach using secondary data of medical records of the East Java SPN students batch 2017/2018. The samples were selected by simple random sampling. Result: Out of 50 students, the mean of age was 19.62 years. All samples were male with mean 559.17 and standard deviation (SD) 959.86. The calculation of the 4000 Hz frequency threshold value obtained an average value of 31.52 and SD of 13.4. Hearing loss complaint was found in 1 student (2%). No complaints of tinnitus and vertigo were found. Statistical tests with Pearson correlation between serum MDA levels and 4000 Hz frequency threshold values showed a correlation coefficient (r) of 0.74 and p = 0.00 (p<0.05). Conclusion: There was a significant correlation between MDA levels and the hearing threshold at 4000 Hz frequency after gunshot exposure in East Java SPN students. Keywords: acoustic trauma, malondialdehyde, hearing threshold level at frequency 4000 Hz ABSTRAK Latar belakang: Insiden trauma akustik pasca pajanan letusan senjata api pada siswa Sekolah Polisi Negara (SPN) cukup tinggi. Malondialdehid (MDA) merupakan senyawa yang dapat menggambarkan stres oksidatif akibat radikal bebas. Adanya hubungan antara kadar MDA dengan nilai ambang dengar frekuensi 4000 Hertz (Hz) dapat menjadi dasar pemberian antioksidan untuk pencegahan trauma akustik. Tujuan: Membuktikan hubungan antara kadar MDA dengan nilai ambang dengar frekuensi 4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur. Metode: Penelitian ini adalah observasional analitik dengan pendekatan retrospektif cross sectional menggunakan data sekunder berupa rekam medik siswa SPN Jawa Timur angkatan 2017/2018. Sampel dipilih secara simple random sampling. Hasil: Dari 50 siswa, usia rerata adalah 19,62 tahun. Seluruh sampel penelitian adalah laki-laki, rerata=559,17 dan standar deviasi (SD)=959,86. Penghitungan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil nilai rerata=31,52 dan SD=13,4 Keluhan penurunan pendengaran hanya dijumpai pada 1 siswa (2%). Uji statistik dengan korelasi Pearson antara kadar MDA dalam serum dengan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil koefisien korelasi (r) sebesar 0,74 dan p = 0,00 (p<0,05). Kesimpulan: Terdapat hubungan yang signifikan antara kadar MDA dengan nilai ambang dengar frekuensi 4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur. Kata kunci: trauma akustik, malondialdehid, nilai ambang dengar frekuensi 4000 Hz

Correlation of malondialdehyde and hearing threshold level at frequency 4000 Hz post gunshot exposure