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Tumor needs new blood vessel formation to grow and metastasize. New blood vessel formation is known as angiogenesis. Angiogenesis is determined by Microvessel Density (MVD) using immunohistochemical examination. Angiogenesis was affected by various angiogenic factors. Recent studies found elevated COX-2 expression in cancers. COX-2 can stimulate angiogenic factors. This research assessed the correlation between COX-2 and angiogenesis, determined by MVD. Purpose: To find out the correlation between COX-2 and MVD in nasopharyngeal carcinoma in H. Adam Malik Hospital. Method: This is a cross sectional analytical research. Twenty four samples was observed by immunohistochemical examination for COX-2 expression and MVD. The results then were analyzed using Spearman correlation test. Result: Positive COX-2 expression was found in 17 (70.83%) subjects and negative in 7 (29,17%) subjects. High MVD was found in 17 (70.83%) subjects and low MVD was found in 7 (29.17%) subjects. There was moderate positive correlation between COX-2 expression and MVD (r=0,559; p=0,005). Conclusion: COX-2 is moderate positively correlated with MVD in nasopharyngeal carcinoma.

Korelasi positif ekspresi cyclooxygenase-2 dengan microvessel density pada karsinoma nasofaring