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Traditional Chinese medicine (TCM) has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers. 3- epi -bufotalin is an active ingredient of TCM “Chanpi” with anti-tumor potential. However, the effect and mechanism of 3- epi -bufotalin on colorectal cancers were not well disclosed. The present study demonstrated that 3- epi -bufotalin could reduce viability, trigger apoptosis, and block the cell cycle at the G 2 /M stage in colorectal cancer cell lines HT29, RKO, and COLO205  in vitro . Moreover, 3- epi -bufotalin inhibited the JAK1/STAT3 signaling pathway. These results indicated the anti-proliferation ability of 3- epi -bufotalin in colorectal cancer cells.

3- epi -bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway