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Available reports have confirmed a link between bacterial infection and the progression of different types of cancers, including colon, lungs, and prostate cancer. Here we report the  Chlamydia pneumonia  proteins targeting in endoplasmic reticulum (ER) using  in-silico  approaches and their possible role in lung cancer etiology. We predicted 48 proteins that target human ER, which may be associated with protein folding and protein-protein interactions during infection. The results showed  C. pneumoniae  proteins targeting human ER and their implications in lung cancer growth. These targeted proteins may be involved in competitive interactions between host and bacterial proteins, which may change the usual pathway functions and trigger the development of lung cancer. Moreover,  C. pneumoniae  unfolded protein accumulation in the human ER possibly induces ER stress, consequently activating the unfolded protein response (UPR), and providing a favorable microenvironment for cancer growth. The current study showed the  C. pneumoniae  protein targeting in ER of host cell and their implication in lung cancer growth. These results may help researchers better manage lung cancer and establish a molecular mechanism for  C. pneumoniae  lung cancer association.

biocell

Proteome-wide screening for the analysis of protein targeting of  Chlamydia pneumoniae  in endoplasmic reticulum of host cells and their possible implication in lung cancer development