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Background: The purpose of this study was to investigate the effectiveness of aerobic training with supplementation of vitamins C and E on some inflammatory markers and cardiovascular risk factors in overweight men.  Methods: In this semi-experimental study, 30 overweight men were randomly assigned into three groups (n=10, AT+Sup, AT+Placebo, and control). The exercise program consisted of three sessions per week at the intensity of 60-75% of maximal heart rate for six weeks. The supplement group received 300 mg of vitamin E daily and 400 mg vitamin C tablet and the placebo group received one gelatin capsule daily during this period. Before and after six weeks of intervention, were measured interleukin-6 (IL-6), -reactive protein (CRP), Triglyceride (TG), Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), and insulin resistance index. Data were analyzed by t-test, one-way ANOVA, and Tukey post hoc test at a significance level of P&lt;0.05. Result: The results showed that aerobic training significantly reduced the body fat percentage, TG, and LDL in both supplement and placebo groups(P&lt;0.05). However, this reduction was observed in IL-6 and CRP only in the supplement group (P&lt;0.05). On the other hand, the results showed that exercise and supplementation did not change the insulin resistance of subjects. The results of one-way ANOVA showed that there was a significant difference between the three groups in fat percentage, IL-6, CRP, TG, and LDL (P&lt;0.05). Conclusion: According to the results of this research, probably six weeks of aerobic training plus supplementation with vitamin E and C may help to reduce inflammatory symptoms, body fat percentage, and some cardiovascular risk factors.

journal of research and health

The Effectiveness of Aerobic Training With Supplementation With Vitamins C and E on Some Inflammatory and Cardiovascular Risk Factors in Overweight Men