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Background: Patients can be carriers of the virus for a long time or become re-infected or re-infected following the use of immunosuppressive drugs. Clinical manifestations in patients are very diverse and can range from asymptomatic to severe illness with death. Patients may also present with manifestations such as coagulation disorders, cardiac dysfunction and arrhythmias, acute coronary syndrome, kidney injury, liver injury, Refer to diabetic hyperglycemia and ketoacidosis. This is an essential point in the prevention of Coronavirus Disease 19 (COVID-19). Case Presentation: We reported a case in which the Polymerase Chain Reaction (PCR) test was positive after re-negative after 5 months. Moreover, the patient presented different and more severe symptoms than the previous infection, as the genetic difference between the strains increased over time. Conclusion: As a result, immunization may become more complicated, and different clinical pictures occur; thus, this condition can challenge vaccine immunization.

The Alteration of Clinical and Laboratory Signs and Symptoms of COVID-19 in Re-infection: A Case Report