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Opioids hijack learning and memory formation mechanisms of brain and induce a pathological memory in the hippocampus. This effect is mainly mediated by modifications in glutamatergic system. Speaking more precisely, Opioids presence in a synapse inhibits blockage of N-Methyl-D-Aspartate Receptor (NMDAR) by Mg 2+ , enhances conductance of NMDAR and thus, induces false Long-Term Potentiation (LTP).

Assessing the Effects of Opioids on Pathological Memory by a Computational Model