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Consuming antidepressant medications induce several problems leading to the need for alternative agents for emotional disturbances. Antidepressant medications increase the seizure risk; thus, alternative treatments, like Antiepileptic Drugs (AED), might be useful for patients with epilepsy comorbid with a psychiatric disorder. The present study evaluated the behavioral effects of sodium valproate, a none effective dose in seizure treatment [100 mg/kg; Intraperitoneal (IP)] along with the application of Low-Frequency Stimulations (LFS) during CA1 hippocampal kindling.

basic and clinical neuroscience/iranian journal of neuroscience

Therapeutic Effects of Sodium Valproate Combined With Low Frequency Electrical Stimulations On Seizure Severity and Behaviors During CA1 Hippocampal Kindling in Adult Male Rat