English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Alzheimer’s disease (AD) is the commonest form of dementia worldwide. The modalities to diagnose AD are generally expensive and limited. Both CNS and Retina are derived from cranial neural crest, so the changes in retinal layers may reflect the changes in CNS tissue. Optical Coherence Tomography (OCT) machine can show the delicate retinal layers and is widely used in retinal disorders. The purpose of this study is to find a new biomarker to help clinicians diagnose AD by the means of retinal OCT examination. Methods: After considering the inclusion and exclusion criteria, 25 patients with mild and moderate AD and 25 normal matched subjects were enrolled in the study. OCT was done for all eyes. Central Macular thickness (CMT) and Ganglion Cell Complex (GCC) thickness were calculated. Groups were compared using SPSS 22 software. Results: Both GCC thickness and CMT were significantly decreased in patients with AD, compared to healthy age and sex matched subjects. Conclusion: Retinal changes, specifically CMT and GCC thickness, may reflect the AD process in brain. OCT may be considered as a non-invasive and inexpensive means to help diagnose the AD.

basic and clinical neuroscience/iranian journal of neuroscience

Retinal Ganglion Cell Complex in Alzheimer Disease: Comparing Ganglion Cell Complex and Central Macular Thickness in Alzheimer Disease and Healthy Subjects Using Spectral Domain-Optical Coherence Tomography