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T he protonation constant (pK a ) of rivastigmine, galantamine and donepezil which are cholinesterase inhibitors used in cure of Alzheimer's disease in acetonitrile-water binary mixtures were determined at 25  o C in ionic strength by spectrophotometric method. Spectra of the drugs were recorded with 1 nm resolution over the 200 to 400 nm interval. Data assessment was carried out with the STAR software program to calculate molar absorbances and stability constants of the compounds studied. A queous  protonation  constant of these compounds were calculated from determined through linear  relationship between the mole fraction of acetonitrile and the  pK a  v alues and the Yasuda-Shedlovsky equality.  The pK a  values of inhibitors at 25°C were converted to values at 37°C, without extra estimation. The predicted and calculated pK a  values were compared with literature values.

Determination of spectrophotometric protonation constant of cholinesterase inhibitors