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Diabetes mellitus is a metabolic disorder. This review article is planned to The anti-diabetic effect of Withania Coagulans have been successfully used in Ayurvedic and other traditional formulations and found to be efficient and inexpensive as compared to synthetic drugs. It also aims to test and verify the W. coagulans fruits, showed significant inhibition on postprandial rise in hyperglycemia post-sucrose load in normoglycemic rats as well as streptozotocin-induced diabetic rats. which is comparable to the standard antidiabetic drug Glibenclamide for medical care, The present study defines the systematic evaluation and the role of minerals in glycemic potential of aqueous extract of Withania coagulans fruits in order to develop an effective and safe alternative treatment for diabetes mellitus. These studies conducted to determine the antidiabetic effect of Withania coagulans and pancreatic histological features in streptozotocin induced diabetic rat. Results: The study is based on results of lowering in blood glucose levels of normal, sub, mild diabetic rats assessed during fasting blood glucose, glucose tolerance test studies. The dose of 1000mg/kg was identified as the most effective dose, which reduce the blood glucose level maximum by 35.2% at 5 hours in normal rats during blood glucose studies. Glucose tolerance test studies is normal, sub and mild diabetic rats showed the maximum reduction of 16.7, 29.8 and 38.5% at 4hour respectively. Long term study incase of severely diabetic rats showed reduction fasting glucose level respectively after 30 days of treatment. The present study confirming antidiabetic effect of aqueous extract of Withania Coagulans, helps in identifying the role of trace minerals like Mg and Ca responsible for antidiabetic potential of this potent indigenous shrub. Conclusion: The present research has presented comprehensive details of antidiabetic plants used in the treatment of diabetes mellitus. Most of these plant derived medicines. Keywords: Anti-Diabetic effect, Screening & Evaluation, Streptozocin, Glibenclamide, Diabetic rats.

SCREENING & EVALUATION OF ANTI-DIABETIC SPECTRUM OF WITHANIA COAGULANS