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Refractory epilepsy is a failure of two (2) appropriately used anti epileptics (AED). This study Is a comparative study of clobzam use as add on with phenytoin and carbarnazepine. Aims & Objectives: Aim of this study is to know how much Clobazam is effective as add on therapy in refractory epilepsy. Material and Methods: In this study two refractory groups of epilepsy are selected. group - 1 is refractory with phenytoin and Group-II with Carbamazepine. Clobazam(10mg) was added to both refractory groups and follow up For 3 Years. Results: There is significant reduction in seizure frequency after addition of clobazam in both refractory groups and 25% Patients were becomes completely seizure free. Discussion: This study was conducted in ANMMCH, Gaya Patients were selected from both outdoor & Indoor of Medicine department and found 77.16% reduction in seizure frequency in group —I i;e with phenytoin and clobazam 78.16% in Group-II z;e with carbamazepine and clobazam and 25% Patients becomes completely seizure free. Conclusion: Clobazam is a very effective and safe AED for add on Therapy. Keywords: Refractory epilepsy Add on therapy mean seizure frequency

COMPARATIVE STUDY OF CLOBAZAM USED AS AN ADD ON THERAPY WITH PHENYTION AND CARBAMAZEPINE IN REFRACTORY EPILEPSY.