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Corresponding author: Rahma Anindya Prathitasari, r.anindya28@gmail. com proliferation that contributes to the progressivity of RA.1-7 Methotrexate is known to trigger liver dysfunction as side effect. Liver function is evaluated based on alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) serum titer. Elevation of liver enzyme above the upper limit indicates liver dysfunction. Based on study in India on 30 patients who were treated with MTX for 3 months, there was 25% elevation of AST above normal range.8 Study in Israel on 119 patients who were treated with MTX showed 43% of RA patients have abnormal liver enzyme titer.9 Study in Iran on 286 patients who were treated with MTX found that 23.7% of patients have experienced liver dysfunction.10 Based on the previous studies, factors that suspected association with liver dysfuction are gender, age, MTX cumulative dose, and MTX duration therapy.8-11 There is not any study about proportion of liver dysfuction on RA patients who are treated with MTX in Indonesia. The purpose of this study is to have the proportion of liver dysfunction in patients who are treated with MTX, and to analyze the association between age, gender, MTX cumulative dose, MTX therapy duration with liver dysfunction incidence, so that clinicians will be more aware with MTX use in patients.

indonesian journal of rheumatology/indonesian journal of rheumatology

Proportion and Factors that Associate with Incidence of Hepatotoxicity in Rheumatoid Arthritis Patients Treated with Methotrexate in RSCM Year 2013âˆ’2015