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Up to now, derivatives of usnic acid were only prepared by classical methods of refluxing in organic solvents for hours. In this study, we examined the condensation reaction of usnic acid with o-toluidine under microwave irradiation condition which gave good yield in a short time. The obtained optimal condition was applied to prepare some other derivatives of (+)-usnic acid.

Preparation of some derivatives of (+)-usnic acid with aromatic amines under microwave irradiation condition