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The functional plasticity of the brain decreases during ageing causing marked deficits in contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a prime example of hippocampal plasticity promoting the contextualization of information but how it influences brain’s activity to improve flexible learning is not known. We asked whether a geneticallydriven expansion of neural stem cells would compensate the natural decline in neurogenesis and rescue agedependent deficits on hippocampal physiology and function. We found that neurogenesis promoted the sparsity of memory representations and changed neural activity patterns underlying consolidation. Remarkably, increased neurogenesis also rescued the age-dependent loss in contextual learning, allocentric navigation and episodic memory. Together, our rejuvenation strategy shows that critical aspects of hippocampal physiology can be reversed in old age by exploiting the brain’s endogenous reserve of neural stem cells.

Increasing Neurogenesis in Old Mice Rejuvenates Hippocampal Function and Memory