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Large offspring syndrome (LOS) is a fetal overgrowth condition observed in some bovine offspring produced in vitro. The main phenotypes of LOS is large body size due to overgrowth during development which can result in difficult birth, can lead to death of the dam and/or calf and can lead to financial losses to producers. Currently, no method exists that can be used to identify LOS during pregnancy. The goal of this study is to investigate if ultrasonographic measurements at day 55 of gestation and maternal blood biomarkers at day 55 and day 105 can be helpful to detect LOS carrying pregnancies. Chapter 1, the literature review, will introduce LOS its phenotypes and molecular associations as well as the conditions that can potentiate LOS. In addition, two examples of spontaneous LOS and their associated financial losses are discussed. Chapter 1 will also introduce the usefulness of ultrasonographic fetometry and maternal blood biomarkers in bovine. Chapter 2, the research chapter, was set to determine if LOS in cattle is identifiable in the maternal blood during pregnancy and/or if fetal ultrasonographies of day 55 gestation may be used for the same purpose. Data included are: characterization of phenotypes associated with LOS, description of maternal white blood cell transcriptomes and information pertaining fetal size as determined by ultrasonographies and after collection of day 56 and 105 fetuses. This chapter has been submitted as a manuscript and it is currently under review.

Efforts to identify large offspring syndrome during pregnancy through ultrasonography and maternal blood transcriptome analyses