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In order to evaluate the leukocytic response to Pegbovigrastim in Holstein cows in the puerperium, 20 females were divided into two groups: the control group, receiving a placebo, and the treatment group, receiving 15 mg of Pegbovigrastim. There was variation in the number of leukocytes (p<0.0001) between groups, mainly due to an increase in the number of segmented neutrophils: on day 7 postpartum, the treatment group presented 19,935.5 ± 11,453.38 cells/μL of blood, while the control group 3,395.75 ± 1,518.87 cells/μL of blood (p<0.0004). There were no significant differences in uterine cytology. It can be concluded that Pegbovigrastim causes an increase in circulating of leukocytes, especially postpartum segmented neutrophils.

Effect of Pegbovigrastim on the leukocyte response of postpartum Holstein cows