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The present opinion piece starts with a compelling and novel hypothesis regarding immunological aspect of the SARSCoV-2 infection, providing valuable insights into the less-appreciated interaction between the causative pathogen behind COVID-19 and type-1 macrophages via alpha-7 nicotinic receptor. However, the manuscript falls short at delivering the hypothesis in question in a conclusive manner, leaving the reader with an incomplete piece, that can also be quite confusing at times.

Review of: "Implications of the SARS-CoV-2 spike protein interaction with type-1 macrophages via α7-nAChR."