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Authors are to be commended for the originality of the study as an attempt to enlarge basic knowledge about the multifactorial pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ). T he goal of this study is noteworthy as the understanding of tissue changes in the jaw of individuals treated with NBP who don't have BRONJ has only been studied in animals. T herefore, the potential impact of this study is very sound. T he sample size is a real strength of the study. However, the histological data presented are only descriptive and the lack of detailed quantitative data represents a limitation of the study, at present. According to the most recent version of the American Association of Oral and Maxillofacial Surgery (AAOMS) consensus paper ,[1]​ diagnosis of MRONJ is purely clinical and related to the presence of exposed jaw bone or bone that can be probed through an intraoral/extraoral fistula. Patients with signs and symptoms other than exposed jaw bone or bone probing fistulas continue to remain excluded from MRONJ case definition.[2]​ In an attempt to properly address potential ONJ patients presenting with minor clinical signs, radiological imaging and Computed T omography (CT ) in particular have been included in the diagnostic process of MRONJ (Italian consensus) to better Qeios, CC-BY 4.0 · Review, June 24, 2019

Review of "Exposure to antiresorptive therapy with bisphosphonates does not induce histological changes in human alveolar jawbone"