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HPLC methodology with a fluorescent detector is suitable for bioavailability studies of investigated generic tablets Mesalazine 250 mg (Jelfa. Poland) versus standard Salofalk tablets (Dr. Falk, Germany). The investigations were completed in ten healthy subjects in a double way crossover design. Only one bioavailability parameter time for maximum mesalazine plasma concentration (t(max)) and overall elimination rate constants are significantly greater for the above standard tablets. The parameters like maximum plasma drug concentration (C-max), lag time for absorption (T-lag), biological half-life time (t(1/2)) are also more favorable for the standard, but these values are not significantly different.

Bioavailability of mesalazine from two coated formulation tablets