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Although longan fruit seeds are waste, they contain phytochemical compounds that can be used as antibacterial. The purpose of this study is to determine the Minimum Inhibitory Concentration (MIC) and Minimum Killing Concentration (MKC) of longan seeds extract on the growth of Staphylococcus aureus and Propionibacterium acnes. The test material was made from dry simplicial and was extracted using 96% ethanol through the sokhletation method. Additionally, the MIC and MKC values were tested using the liquid dilution method. The results indicate that the Minimum Inhibitory Concentration of longan fruit extract on the growth of Staphylococcus aureus and Propionibacterium acne is 2% w / v while the Minimum Killing Concentration for both bacteria is 3% w / v. Keywords: Extraction, MIC, MKC, Staphylococcus aureus, and Propionibacterium acne Biji Buah Kelengkeng merupakan limbah, tetapi mengandung senyawa fitokimia yang dapat dimanfaatkan baik sebagai antibakteri.. Tujuan penelitian ini adalah untuk menentukan konsentrasi Minimum Inhibitory Concentration (MIC) dan Minimum Killing Concentration (MKC) dari ekstrak biji buah kelengkeng terhadap pertumbuhan Staphylococcus aureus dan Propionibacterium acne . Bahan uji dibuat simplisia kering, diekstraksi dengan etanol 96 % dengan metode sokhletasi,  diuji nilai MIC dan MKC dengan metode dilusi cair. Hasil yang diperoleh menunjukkan bahwa Minimum Inhibitory Concentration ekstrak biji buah kelengkeng terhadap pertumbuhan Staphylococcus aureus dan Propionibacterium acne adalah 2 %b/v dan Minimum Killing Concentration untuk kedua bakteri tersebut adalah 3 %b/v. Kata Kunci : Ekstraksi,  MIC, MKC, Staphylococcus aureus dan Propionibacterium acne

EFEKTIFITAS EKSTRAK BIJI BUAH KELENGKENG (Euphoria longan Stend) TERHADAP PERTUMBUHAN Staphylococcus aureus dan Propionibacterium acne