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Myo-inositol is an essential component of human metabolome: for at least 120 inositol phosphate-dependent proteins, there is reliable information  about  their  specific  participation  in  maintaining  of  reproductive  system  functioning,  embryo  development,  fetal  brain neuroprotection, and insulin signaling cascade activity. Accordingly, metabolic disorders of the myo-inositol lead to insulin resistance, cell  resistance  to  gonadotropin-releasing  hormone,  follicle-stimulating  and  luteinizing  hormones,  ovulation  disorders,  inhibition of  oocyte  maturation.  An  involvement  of  myo-inositol  phospho  derivatives  in  intracellular  signal  transmission  from  reproductive hormones receptors determines effectiveness of myo-inositol drug action on normalizing processes of reproductive hormone levels and ovulation. Use of the myo-inositol  is effective in the treatment of polycystic ovarian syndrome and reduces a risk of folate-resistant developmental malformations.  It  is also promising to use the myo-inositol  for  in vitro fertilization (IVF) preparation. Meta-analyzes of randomized trials have confirmed myo-inositol efficacy (2–4 g/day, at least 3 months) in increasing of frequency of pregnancy in infertile women who undergo induction of ovulation or  in vitro embryo transplantation. The data cited above indicate  importance of establishing availability of myo-inositol to patients undergoing the IVF, as myo-inositol level in the blood is an important biomarker of women’s somatic and reproductive health. An effective method of correcting reproductive disorders in women is the use of myo-inositol (especially in combination with folates).

Roles of myo-inositol in maintaining women’s reproductive health. Increase effectiveness of in vitro fertilization techniques