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Last year, we were all reminded about the 200th anniversary of James Parkinson’s “Essay on the Shaking Palsy” (one can hardly label this as a celebration, as it would have been much better if this anniversary had never taken place). At the Journal of Parkinson’s Disease, we chose to publish a special issue last year that highlighted eight of the most important advances in Parkinson’s research over the past 60 years, and we were fortunate to have several scientists who made those original findings contribute review articles [1–8]. It was fascinating to read personal accounts of how major strides had been made, and to get a look behind the scenes of some remarkable discoveries. As we were working on that special issue, we frequently commented on how the pace of research into Parkinson’s disease has accelerated to a sometimes remarkable extent in recent years. Several of the discoveries made during the past two decades have been driven by the availability of advanced and automated laboratory apparatus, molecular technologies, computer science and bioinformatics. On the clinical side, the development of advanced brain imaging techniques and the realization of the importance of large clinical cohorts and collection of biosamples have speeded up further discoveries. We started to discuss what the future might hold, and we speculated that we might see more advances in the treatment and

The Times They Are a-Changin’: Parkinson’s Disease 20 Years from Now