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The aim of this paper was to study the elastic and electrical properties of lymphoid cells in patients with acute lymphoblastic leucosis (ALL, n = 15). The mechanical properties of the membrane of lymphoid cells was recorded by atomic force microscopy (AFM). The electrical properties of the lymphoid cell membranes were detected by the Kelvin method. The elastic and electrical membrane properties of lymphoid cells were recorded by incubation with doxorubicin, one of chemotherapy drugs. We used different concentrations and incubation time. It was shown that in the acute phase of the disease and the stage of stable remission the lymphoid cell clones with a reduced stiffness and increased cell surface charge were found. In the experiments in vitro was demonstrated that the increased cell membrane rigidity may be one of the factors determining the tumor cell resistance to the chemotherapy. It was found that if to use the highest concentration of drug in the incubation medium (0.5–1.0 mg/ml) and its longest time, then the surviving cells had more elastic membrane (0.25–1.0 Pa) and the positive potential of the membrane surface (15–29 mV). These obtained data may have a significant prognostic importance for the evaluation of drug resistance of tumor cells.

Micromechanical properties of lymphoid cells in patients with acute lymphoblastic leucosis