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1Note: The transcript has been edited for clarity and accuracy. on alternatives to factor analysis for defining insulin resistance syndrome (IRS). I will be using an alternative to standard meta-analysis that I developed for studying Apolipoprotein E (ApoE), AD, and mortality. Perhaps I can start with a question. There is a huge literature correlating ApoE genotype and anything else you can think of. However, I was struck with your comments on how ApoE might come into the IRS-depression link. I wonder if you could comment on that.

Alzheimer Research Forum Live Discussion: Insulin Resistance: A Common Axis Linking Alzheimer's, Depression, and Metabolism?1