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The present commentary is based on a thought – provoking and experiment – driven manuscript entitled “Supplementation with apple juice attenuates presenilin – 1 overexpression during dietary and genetically – induced oxidative stress” by A. Chan and T.B. Shea (University of Massachusetts Lowell, Lowell, MA) [2]. The manuscript’s highlights are discussed, with a short review of the current perspective on the important topic of the effects of dietary supplementation on Alzheimer’s disease (AD). The manuscript is focused to how apple juice concentrate (AJC) modulates the expression of the important AD – related protein presenilin (PS-1). This is a well – focused and well – defined study that tests a specific hypothesis in a potentially fruitful fashion. Using an interesting animal model, the investigators in the present work have examined the effect of dietary supplementation of AJC on the overexpression of PS-1, whose variant form participates in the overproduction of amyloid β-peptide (Aβ), a major hallmark of AD. Notably, this work shows that AJC attenuates PS-1 overexpression during dietary and

journal of alzheimer's disease

Where the actions of environment (nutrition), gene and protein meet: Beneficial role of fruit and vegetable juices in potentially delaying the onset of Alzheimer's disease