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An aged Barbary ape (Macaca sylvanus) at the Toronto Zoo became infected with naturally acquired West Nile virus encephalitis that caused neurologic signs, which, associated with other medical problems, led to euthanasia. The diagnosis was based on immunohistochemical assay of brain lesions, reverse transcriptase-polymerase chain reaction, and virus isolation.

West Nile Virus Encephalitis in a Barbary Macaque (Macaca sylvanus)