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To the Editor: The undersigned, representing interested scientists from both Turkey and the United States, recently visited the water development projects in southeastern Anatolia, Turkey. This letter describes our observations and projections on the possible health-related consequences of these projects with specific emphasis on infectious diseases. When new irrigation schemes are introduced into previously dry areas, disease frequently follows the new water. The Southeastern Anatolia Irrigation Project or GAP (its Turkish acronym) is one of the largest projects ever undertaken in Turkey. This water resources development program includes the construction of 22 dams and 19 hydroelectric plants on the Euphrates and Tigris rivers in southeastern Turkey. Upon completion, the project will also include an irrigation network for 1.7 million hectares of land, covering eight provinces corresponding to approximately 10% of Turkey’s total population and surface area (1). In its entirety, GAP comprises investments in development projects linked to agriculture, energy, transportation, telecommunications, health care, education, and urban and rural infrastructures. To ensure the success of the project, an agency has been established (the Republic of Turkey Prime Ministry Southeastern Anatolia Project Regional Development Administration) to oversee and implement all of these projects. The largest of the completed dams on the Euphrates River is the Ataturk Dam. It is the sixthlargest rock-filled dam in the world; its hydroelectric systems have already produced more than seven billion kilowatt hours of power since 1992 (2). Water from the Ataturk Dam reservoir is diverted to the plains of upper Mesopotamia through the Sanliurfa Irrigation Tunnel System. This system consists of two parallel tunnels, each 26.5-km long and 7.62 m in diameter, and numerous other irrigation networks and canal systems. The first water started to flow to the plains of Harran in November 1994. Additional lands will be incorporated into the irrigation scheme as the canals are completed. (The year 2020 is the target date for completion.) When fully operational, GAP is expected to double Turkey’s hydroelectric production, increase irrigated areas by 50%, more than double the per capita income in the region, more than quadruple the gross national product, and create two million new jobs in the coming decade (3). The total surface area affected by the irrigation scheme is about 75,000 km2; of this, 46.2% is cultivated (36% semiarid rain-fed farmland), 33.3% is dry pastures, 20.5% is forest and bush. One of GAP’s major goals is to remove the socioeconomic disparity between the country’s more developed regions and the project area. For GAP to reach its targeted and sustainable economic aims, projects in various other sectors also need to be considered and integrated. In this context, the public health consequences of emerging diseases in this setting must be anticipated so that appropriate health education and disease prevention measures can be implemented. To anticipate changing patterns in disease associated with microclimatic and other environmental changes, knowledge of existing diseases in the region is vital. Since arthropods, reservoir animals, and other intermediate hosts are involved in the transmission of many waterborne parasitic diseases, a clear understanding of the existing species—especially of insect vectors—is equally important. Historically, occasional cases of malaria have occurred in the region; however, limited records show that this disease is clearly on the rise. Cutaneous leishmaniasis is also endemic and on the rise, but few data are available on the prevalence of the visceral form of the disease. Other common diseases in the region include bacterial and helminthic gastrointestinal infections as well as trachoma. According to data from the Malaria Division of the Turkish Health Ministry, the reported cases of Plasmodium vivax malaria rose from 8,680 in 1990 to 18,676 in 1992 (4). The province of Sanliurfa (population one million in 1990), which is at the heart of the irrigated plains in GAP, has reported that malaria cases increased from 785 in 1990 to 5,125 in 1993. The numbers of cases in the first 9 months of 1994 alone were already significantly higher than those reported in 1993 (S. Aksoy, unpublished data). Although presumably P. vivax malaria is most common, cases of P. falciparum malaria have also been reported in the country. Three cases of P. falciparum malaria were recently documented in Izmir, which is on the Aegean Sea coast of Turkey (4). No cases of drug-resistant malaria have been reported. Another endemic disease on the rise in the southeastern region is leishmaniasis, transmitted by biting sand flies. In Sanliurfa the number of documented cases of the cutaneous form of this disease has risen from 552 in 1990 to 1,955 in 1993. In the first 9 months of 1994 alone, the number of reported cases was more than 3,000 (S. Aksoy, unpublished data). At Sanliurfa’s Diyarbakir Hospital, in 1991, in addition to cases of the cutaneous forms of the disease, there were 80 potential cases of visceral leishmaniasis (kala-azar) in children ages 2 to 10 (5). Leishmania donovani is often the causative agent of kala-azar, but both L. tropica and L. infantum may also be involved (6). As the economic opporLetters

The GAP Project in Southeastern Turkey: The Potential for Emergence of Diseases