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Background: Papillary thyroid carcinoma (PTC) is the commonest thyroid cancer. Cases in category-5a of Bethesda system (suspicious for papillary carcinoma) are treated by surgical lobectomy followedby total thyroidectomy if histopathology confirms papillary carcinoma. In order to reduce surgicalprocedures to one this was conducted.Objectives: evaluation of role of immunohistochemistry in pre-operative diagnosis of papillary thyroidcarcinoma on cell blocks.Materials and Method: Cell blocks were taken from cases labelled category-5a for histopathology andimmunohistochemistry using three markers (CK-19, Thyro-peroxidase, and BRAFv600E mutation).Results: were highly sensitive, and specific. The use of more than markers increases sensitivity of theprocedure.Conclusion: immunohistochemical stains on cell blocks is a reliable method for pre-operative diagnosisof papillary thyroid carcinoma.

Immunohistochemistry on cell blocks a method for pre-operative diagnosis of papillary thyroid carcinoma by FNAC