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Objective : This investigation was undertaken to determine whether a grape seed extract (GSE) that is rich in mono-, oligo- and poly- meric polyphenols would modify postprandial oxidative stress and inflammation in individuals with the metabolic syndrome (MetS). Background : MetS is known to be associated with impaired glucose tolerance and poor glycemic control. Consumption of a meal high in readily available carbohydrates and fat causes postprandial increases in glycemia and lipidemia and markers of oxidative stress, inflammation and insulin resistance. Materials/methods : After an overnight fast, twelve subjects with MetS (5 men and 7 women) consumed a breakfast meal high in fat and carbohydrate in a cross-over design. A GSE (300 mg) or placebo capsule was administrated 1 hr before the meal (-1 hr). Changes in plasma insulin, glucose, oxidative stress and inflammatory markers were measured hourly for 6 hr. Results : Plasma hydrophilic oxygen radical absorbance capacity (ORAC) measured as the positive incremental area under the curve (-1 to 5 hr) was significantly increased when the meal was preceded by GSE compared with placebo (P 0.05). No changes in inflammatory markers were evident. Conclusion : These data suggest that GSE enhances postprandial plasma antioxidant status and reduces the glycemic response to a meal, high in fat and carbohydrate in subjects with the MetS. Key words : Polyphenols, Oxidative stress, Inflammation, ORAC, Oxidized LDL

functional foods in health and disease/journal of functional foods in health and disease

Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome - randomized, cross-over, placebo-controlled study