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Typhus is one of acute febrile illness caused by the bacterium Salmonella typhi. Treatment of typhoid fever usually use antibiotics, the use of antibiotics can cause side effects. People today are using treatment with natural ingredients, one of which is Binahong (Anredera cordifolia) compounds containing alkaloids, polyphenols, flavonoids, saponin, and anthraquinone is efficacious as an antibacterial. This study aims to determine the effectiveness of the water decoction of leaves Binahong against Salmonella typhi growth in vitro. This type of research is true experiment with posttest study design Only Control Group Design and methods used are diffusion (wells) with 5 treatment. The concentration of the cooking water leaves the dgunakan Binahong is 20%, 40%, 60%, 80% and 100%. The result showed inhibition zone water decoction of the leaves Binahong against Salmonella typhi at a concentration of 20%, 40%, 60%, 80% is 0 mm, whereas at 100% concentration obtained inhibition zone of 11 mm. It is concluded that the water decoction of the leaves Binahong at a concentration of 100% has the ability to inhibit the growth of Salmonella typhi, but these results have not been effective because it is still in the category of resistance. It is suggested for further research to increase the concentration of water decoction of the leaves binahong or use alcohol extract of leaves binahong to inhibit the growth of Salmonella typhi. Keywords: Water decoction of leaves Binahong, Salmonella typhi, antibacterial.  Abstrak: Penyakit tifus atau dikenal dengan demam tifoid atau demam enterik adalah salah satu penyakit demam akut yang disebabkan oleh bakteri Salmonella typhi. Pengobatan demam tifoid biasanya menggunakan antibiotik, penggunaan antibiotik dapat menimbulkan efek samping. Masyarakat saat ini banyak menggunakan pengobatan dengan bahan alami, salah satunya adalah Binahong (Anredera cordifolia) yang mengandung senyawa Alkaloid, Polifenol, Flavonoid, Saponin, dan Antrakuinon yang berkhasiat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui efektifitas air rebusan daun Binahong terhadap pertumbuhan Salmonella typhi secara in vitro. Jenis penelitian ini adalah true eksperiment dengan rancangan penelitian Posttest Only Control Group Design dan metode yang digunakan adalah difusi (sumuran) dengan 5 perlakuan. Konsentrasi air rebusan daun Binahong yang dgunakan adalah 20%, 40%, 60%, 80% dan 100%. Hasil penelitian didapatkan zona hambat air rebusan daun Binahong terhadap Salmonella typhi pada konsentrasi 20%, 40%, 60%, 80% adalah 0 mm, sedangkan pada konsentrasi 100% didapatkan zona hambat sebesar 11 mm. Kesimpulan penelitian ini adalah air rebusan daun Binahong pada konsentrasi 100% memiliki kemampuan menghambat pertumbuhan Salmonella typhi, namun hasil ini belum efektif karena masih dalam kategori resisten. Disarankan bagi peneliti selanjutnya untuk meningkatkan konsentrasi air rebusan daun binahong atau menggunakan ektrak alkohol daun binahong untuk menghambat pertumbuhan Salmonella typhi. Kata kunci : Air rebusan daun Binahong, Salmonella typhi, antibakteri.

Efektivitas Air Rebusan Daun Binahong (Anredera cordifolia) Terhadap Pertumbuhan Salmonella typhi