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Binahong leaves contain flavonoid and polyphenol compounds that are potentially free radical scavengers. Extraction using ultrasonic has been carried out at various extraction times and temperatures. The purpose of this study was to obtain the optimum time and temperature of ultrasonic for yield and free radical scavenging activity of binahong leaves using Response Surface Methodology (RSM) with the Central Composite Design method. Binahong leaves were extracted at three levels of time (10, 20, 30 minutes) and temperature (40, 45, 50°C) with a frequency of 40 kHz using an ultrasonic bath. The results showed at a temperature of 45°C for 20 minutes obtained the highest yield of 10.44%, with a predictive value of RSM 10.15%. At a temperature of 40°C for 30 minutes, the optimum value of the free radical scavenging activity of binahong leaf extract was obtained. The percent inhibition value was 55.92%, with a predictive value of 48.85%. Based on the results, the temperature and time variables have a significant effect on the percentage of extract yield and have no significant effect on free radical scavenging activity.Keywords:  Binahong, Response surface methodology, Yield, free radical scavenging activityPemanfaatan Ekstrak Daun Binahong (Anredera cordifolia ) Asal Kabupaten Bogor Sebagai Penangkal Radikal BebasABSTRAKDaun binahong memiliki senyawa flavonoid dan polifenol yang berpotensi sebagai penangkal radikal bebas. Telah dilakukan ekstraksi dengan menggunakan bantuan gelombang ultrasonic yang dilakukan dengan berbagai waktu dan suhu ekstraksi. Tujuan dari penelitian ini yaitu diperolehnya waktu dan suhu optimum ekstraksi berbantu gelombang ultrasonik terhadap rendemen ekstrak dan aktivitas penangkal radikal bebas daun binahong dengan menggunakan Response Surface Methodology (RSM) metode Central Composite Design. Daun binahong diekstraksi dengan 3 taraf waktu (10, 20, 30 menit) dan suhu (40°C, 45°C, 50°C) dengan frekuensi 40 kHz dengan menggunakan ultrasonic bath. Hasil penelitian menunjukkan bahwa pada suhu 45°C pada waktu 20 menit diperoleh hasil rendemen ekstrak tertinggi yaitu 10,44% dengan nilai prediksi RSM 10,15% dan pada suhu 40°C dengan waktu 30 menit diperoleh nilai optimum terhadap aktivitas penangkal radikal bebas ekstrak daun binahong yaitu diperoleh nilai persen inhibisi 55,92% dengan nilai prediksi 48,85%. Berdasarkan hasil penelitian, menunjukkan bahwa variabel suhu dan waktu hanya berpengaruh nyata terhadap persentase rendemen ekstrak dan tidak berpengaruh nyata terhadap aktivitas penangkalan radikal bebas.Kata kunci: Binahong, Response surface methodology, Rendemen ekstrak, Aktivitas penangkal radikal bebas

Utilization of Binahong (Anredera cordifolia) Leaves Extract from Bogor Regency as Free Radical Scavenging Activity