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Due to the strong immunomodulatory effects, vitamin D (Vit-D) may be an option in COVID-19 disease The skin pigment melanin has the photoprotective capacity, by inhibiting the synthesis of Vit-D in human Dark skin contains a high level of melanin, which inhibits vit-D synthesis, leading to deficiency of this vitamin in certain people worldwide It has been reported that the angiotensin II stimulates melanogenesis process The SARS-CoV-2 uses the ACE2 receptor for the entrance into the human lung epithelial cells Therefore, there is an interconnection between the ACE2, angiotensin II, melanogenesis and Vit-D levels in our body An upregulation of angiotensin II is inversely co-related to the Vit-D synthesis in human Taken together, SARS-CoV-2 may rule over the peoples having high skin melanin contents and its consequence of Vit-D deficiency This review aims to highlight a correlation between skin melanin content, Vit-D status, immunity and the potential effects on SARS-CoV-2 prevalence in COVID-19 patients As a novelty of this review, clinical trials on Vit-D aiming to fight against SARS-CoV-2 related pathological conditions or comorbidities in COVID-19 were included The results of the analysed data showed that there is scientific evidence that a potential synergistic treatment with Vit-D could reduce the risk of SARS-CoV-2 infection and COVID-19 deaths © 2020, Romanian Society for Pharmaceutical Sciences All rights reserved

HIGH SKIN MELANIN CONTENT, VITAMIN D DEFICIENCY AND IMMUNITY: POTENTIAL INTERFERENCE FOR SEVERITY OF COVID-19