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The study is presenting the formulation and manufacturing process of 15 hydrogels formed by different cellulose derivative containing 1% naftifine hydrochloride dissolved in a mixture of cosolvents with low amounts of alcoholic components. The obtained products were evaluated by modelling their flow behaviour and by studying the in vitro release profile in vertical diffusion cell systems. The formulations showed a typical pseudoplastic behaviour. The range of variation in diffusion coefficient values is remarkably low, compared to structural differences easily detectable and demonstrated by rheological behaviour analysis. The increase in the concentration of the cellulose derivative matrix former leads to proportional decreases in diffusion coefficient values for naftifine, correlated with structural parameters.

RHEOLOGICAL BEHAVIOUR AND IN VITRO RELEASE PROFILES OF NAFTIFINE TOPICAL HYDROGELS