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The goal of this work was the studying and modelling of the extraction properties of fluoroorganic solvents in regard to lowpolar biologically active substances (BAS) from plant raw materials (PRM). Anethum graveolens L., Foeniculum vulgare Mill., Pastinaca sativa L., Pimpinella anisum L., Silybum marianum L. fruits, Curcuma longa L. roots, Eucalyptus viminalis Labill., Laurus nobilis L. leaves, Hypericum perforatum L. herbs, and Syzygium aromaticum L. buds were used. As solvents, we used Novec 1230, Novec 7100, MR6S4, and R141b. Quantitative and qualitative analyses of BAS were carried out by RP HPLC and GC-MS. We also used a circulating method in Soxhlet apparatus. A mathematical model that quantitatively describes the extraction properties of fluoroorganic solvents using molecular descriptors such as the relative fraction of fluorine atoms in the molecule of the fluoroorganic solvent and LTPSA has been developed.

STUDY AND MODELING OF EXTRACTION PROPERTIES OF FLUOROORGANIC SOLVENTS IN REGARD TO LOW-POLAR BIOLOGICALLY ACTIVE SUBSTANCES FROM PLANT RAW MATERIALS