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The purposes of the study were the comparison between the levels of different polyphenol groups in Crataegus pentagyna (CP) leaf and Viburnum opulus (VO) fruit extracts, the assessment of their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the in vitro determination of their permeability parameters. CP extract had higher total phenolic, flavonoid and proanthocyanidin contents than VO extract (901.12 ± 3.23 vs. 231.15 ± 1.53 mg chlorogenic acid equivalents/g extract, 416.68 ± 2.03 vs. 95.33 ± 0.95 mg catechin equivalents/g extract and 112.7 ± 1.21 vs. 18.40 ± 0.87 mg cyanidin/g extract, respectively), while both extracts showed promising DPPH scavenging activity (EC50 = 15.56 ± 0.03 and 47.18 ± 0.12 μg/mL, respectively). To investigate whether the sublingual or cutaneous routes are suitable for the administration of CP and VO extracts, permeation and penetration studies were carried out in Franz diffusion cells. The polyphenols of CP and VO extracts had higher transfer across the sublingual porcine membrane (71.93% and 62.65% polyphenols in the receptor compartment, respectively) than across the chicken skin membrane (54.48% and 39.42% polyphenols in the receptor compartment, respectively). The results provide evidence that these extracts can be used to develop oromucosal dosage forms.

CHEMICAL, ANTIOXIDANT AND IN VITRO PERMEATION AND PENETRATION STUDIES OF EXTRACTS OBTAINED FROM VIBURNUM OPULUS AND CRATAEGUS PENTAGYNA