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Despite the treatability and advances in treatment of major depressive disorder (MDD), treatment responsiveness is still only around 30 50%. The involvement of pro-inflammatory factors in the pathogenesis of major depression is one of the new perspectives of current research. This is a prospective study over an 8-week period in 50 MDD patients with single or multiple episodes recruited from the Timișoara Psychiatry Clinic during 2016-2019. Several psychometric measures were applied and baseline for C Reactive Protein (CRP) and Interleukin-6 (IL-6) blood levels were determined. Among the 17item Hamilton Depression Rating Scale (HAM-D), somatic anxiety, somatic symptoms-general and insight had significantly higher scores in MDD patients with elevated inflammatory markers compared to their counterpart with normal inflammatory marker levels (p < 0.05). Add-on celecoxib treatment determined a significantly lowered mean HAM-D scores at endpoint in MDD patients with elevated inflammatory markers (p < 0.01). Linear regression analysis revealed the presence of inflammation (IL-6 and/or CRP) and add-on celecoxib treatment as significantly influencing endpoint HAM-D scores (p < 0.01). Routine determination of inflammatory markers in MDD patients, together with add-on celecoxib treatment, generates new opportunities for the clinical management of this highly frequent psychiatric condition in the general population.

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THE PRESENCE OF PERIPHERAL INFLAMMATORY MARKERS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER, THE ASSOCIATED SYMPTOMS PROFILES AND THE ANTIDEPRESSANT EFFICACY OF CELECOXIB